%0 Journal Article
%@ 1745-6150
%A Dhanda, Sandeep Kumar
%A Vir, Pooja
%A Raghava, G.P.S.
%D 2013
%F open:2436
%I BMC part of Springer Nature
%J Biology direct
%P 30
%T Designing of interferon-gamma inducing MHC class-II binders.
%U http://crdd.osdd.net/open/2436/
%V 8
%X The generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T helper cells play a substantial contribution in the control of infections such as caused by Mycobacterium tuberculosis. In the past, numerous methods have been developed for predicting MHC class II binders that can activate T-helper cells. Best of author's knowledge, no method has been developed so far that can predict the type of cytokine will be secreted by these MHC Class II binders or T-helper epitopes. In this study, an attempt has been made to predict the IFN-γ inducing peptides. The main dataset used in this study contains 3705 IFN-γ inducing and 6728 non-IFN-γ inducing MHC class II binders. Another dataset called IFNgOnly contains 4483 IFN-γ inducing epitopes and 2160 epitopes that induce other cytokine except IFN-γ. In addition we have alternate dataset that contains IFN-γ inducing and equal number of random peptides.
%Z Open Access