TY  - JOUR
N1  - Open Access
ID  - open2436
UR  - https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-8-30
A1  - Dhanda, Sandeep Kumar
A1  - Vir, Pooja
A1  - Raghava, G.P.S.
Y1  - 2013/12/05/
N2  - The generation of interferon-gamma (IFN-?) by MHC class II activated CD4+ T helper cells play a substantial contribution in the control of infections such as caused by Mycobacterium tuberculosis. In the past, numerous methods have been developed for predicting MHC class II binders that can activate T-helper cells. Best of author's knowledge, no method has been developed so far that can predict the type of cytokine will be secreted by these MHC Class II binders or T-helper epitopes. In this study, an attempt has been made to predict the IFN-? inducing peptides. The main dataset used in this study contains 3705 IFN-? inducing and 6728 non-IFN-? inducing MHC class II binders. Another dataset called IFNgOnly contains 4483 IFN-? inducing epitopes and 2160 epitopes that induce other cytokine except IFN-?. In addition we have alternate dataset that contains IFN-? inducing and equal number of random peptides.
PB  - BMC part of Springer Nature
JF  - Biology direct
VL  - 8
SN  - 1745-6150
TI  - Designing of interferon-gamma inducing MHC class-II binders.
ER  -