TY  - JOUR
N1  - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 
ID  - open2453
UR  - https://doi.org/10.3389/fmicb.2013.00332
A1  - Roy, Anupam
A1  - Mahata, Denial
A1  - Paul, Debarati
A1  - Korpole, Suresh
A1  - Franco, Octavio L
A1  - Mandal, Santi M
Y1  - 2013///
N2  - An antifungal lipopeptide fengycin, producing strain SM1 was isolated from farm land soil sample and identified as Bacillus thuringiensis strain SM1 by using 16S rDNA analysis. Fengycin detected in the culture extract was further purified using HPLC and showed a molecular mass of 1492.8 Da by MALDI-TOF-MS analysis. Purified fengycin was allowed to construct their self-assembled structure onto a hydrophobic surface showing a clear improvement of antibacterial activity. In self-assembly, fengycin adapts a spherical micelle core shell like structure. Self-assembled fengycin may be a successful antimicrobial compound modifying its action from confined antifungal function. Besides it can open up a new area of research in supramolecular lipopeptide based compound making. This can revealed the mode of action of this unique self-assembled structure to fully evaluate its potential for use as an antimicrobial drug to control the emergence of bacterial infection. 
PB  - Frontiers Media
JF  - Frontiers in microbiology
VL  - 4
KW  - Bacillus thuringiensis; antimicrobial activity; fengycin; self-assembled structure
SN  - 1664-302X
TI  - Purification, biochemical characterization and self-assembled structure of a fengycin-like antifungal peptide from Bacillus thuringiensis strain SM1.
ER  -