title: Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells.
creator: Raghav, Pawan Kumar
creator: Kumar, Rajesh
creator: Kumar, Vinod
creator: Raghava, Gajendra P S
subject: QR Microbiology
description: Inducing apoptosis in cancer cells is an important step for the successful treatment of cancer patients. Bcl-2 is an antiapoptotic protein which determines apoptosis by interacting with proapoptotic members of the Bcl-2 family. Exome sequencing has identified Bcl-2 and Bax missense mutations in more than 40 cancer types. However, a little information is available about the functional impact of each Bcl-2 and Bax mutation on the pathogenesis of cancer.
publisher: Wiley
date: 2019-11
type: Article
type: PeerReviewed
relation: https://onlinelibrary.wiley.com/doi/full/10.1002/mgg3.910
identifier:   Raghav, Pawan Kumar and Kumar, Rajesh and Kumar, Vinod and Raghava, Gajendra P S  (2019) Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells.  Molecular genetics & genomic medicine, 7 (11).  e910.  ISSN 2324-9269     
relation: http://crdd.osdd.net/open/2488/