%A Pawan Kumar Raghav
%A Rajesh Kumar
%A Vinod Kumar
%A Gajendra P S Raghava
%O Copyright of this article belongs to Wiley
%J Molecular genetics & genomic medicine
%T Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells.
%X Inducing apoptosis in cancer cells is an important step for the successful treatment of cancer patients. Bcl-2 is an antiapoptotic protein which determines apoptosis by interacting with proapoptotic members of the Bcl-2 family. Exome sequencing has identified Bcl-2 and Bax missense mutations in more than 40 cancer types. However, a little information is available about the functional impact of each Bcl-2 and Bax mutation on the pathogenesis of cancer.
%N 11
%K Bax; Bcl-2; apoptosis; cancer; docking; mutation
%P e910
%V 7
%D 2019
%I Wiley
%L open2488