creators_name: Saini, Ankita
creators_name: Mahajan, Sahil
creators_name: Bhagyaraj, Ella
creators_name: Kalra, Rashi
creators_name: Nanduri, Ravikanth
creators_name: Gupta, Ravi
creators_name: Khatri, Neeraj
creators_name: Gupta, Pawan
type: article
datestamp: 2019-12-12 10:10:57
lastmod: 2019-12-12 10:10:57
metadata_visibility: show
title: An Accord of Nuclear Receptor Expression in CD4 T Cells in Rheumatoid Arthritis.
ispublished: pub
subjects: QR
note: Copyright of this article belongs to AAI.
abstract: Chronically activated CD4 T cells drive uncontrolled inflammation, leading to tissue damage in various autoimmune disorders, such as rheumatoid arthritis (RA). Investigation of the molecular mechanisms involved in RA and recent analysis of transcriptomic profiles has implicated members of the nuclear receptor (NR) superfamily in RA. NRs are required for the development, differentiation, and effector function of CD4 T cells; therefore, it is thought that NRs are important in shaping the CD4 T cell repertoire and associated inflammation in RA. Despite their relevance, the full potential of the NR superfamily in RA, either as biomarkers or disease targets, has not been harnessed. To gain insight on the NR members that are closely associated with RA disease activity, we generated an expression atlas for the NR superfamily in CD4 T cells isolated either in a steady state or over the course of collagen-induced arthritis mouse model of RA. We observed discrete expression patterns among the NR superfamily during the disease stages. NRs that instigate anti-inflammatory programs underwent major downregulation during disease onset; however, during the fully developed disease stage we noticed that NRs that induce proinflammatory programs had reduced transcript levels. These animal findings corroborated well with the expression patterns of NRs in clinical samples obtained from RA patients. Furthermore, we observed that targeting NRs using synthetic ligands alleviates the progression of collagen-induced arthritis. Overall, our data demonstrates the potential of the NR superfamily as novel therapeutic targets for the treatment of autoimmune disorders.
date: 2019-08-22
date_type: published
publication: ImmunoHorizons
volume: 3
number: 8
publisher: American Association of Immunologist
pagerange: 402-411
refereed: TRUE
issn: 2573-7732
official_url: https://www.immunohorizons.org/content/3/8/402
citation:   Saini, Ankita and Mahajan, Sahil and Bhagyaraj, Ella and Kalra, Rashi and Nanduri, Ravikanth and Gupta, Ravi and Khatri, Neeraj and Gupta, Pawan  (2019) An Accord of Nuclear Receptor Expression in CD4 T Cells in Rheumatoid Arthritis.  ImmunoHorizons, 3 (8).  pp. 402-411.  ISSN 2573-7732