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primary topic: OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer

OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer
type: AcademicArticle
type: Article
abstract: One of the emerging technologies to fight against cancer is oncolytic virus-based immunotherapy. Recently, the FDA approved an oncolytic virus T-vec for the treatment of melanoma. To facilitate the scientific community, we build a manually-curated repository of oncolytic viruses called OvirusTdb (https://webs.iiitd.edu.in/raghava/ovirustdb/). The repository maintains comprehensive information on therapeutically important oncolytic viruses with 5927 records where each record has 25 fields such as the virus species, cancer cell line, synergism with anti-cancer drugs, and many more. It stores information on 09 types of DNA, 15 types of RNA; 300 recombinant and 09 wild-type viral strains; tested against 124 cancer types and 427 cancer cell lines. Approximately, 1047 records suggest improved anti-cancer response using the combinatorial approach with chemotherapeutic agents. Nearly, 3243 and 1506 records indicate cancer cell death via apoptosis induction and immune activation, respectively. OvirusTdb may facilitate researchers in designing and discovering new oncolytic viruses for effective cancer treatment.
date: 2020-09-10
volume: 548
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR355 Virology

Elsevier Science
type: Organization

Virology
type: Collection

Anjali Lathwal
type: Person
given name: Anjali
family name: Lathwal

G.P.S. Raghava
type: Person
given name: G.P.S.
family name: Raghava

Rajesh Kumar
type: Person
given name: Rajesh
family name: Kumar

HTML Summary of #2604 OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer
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primary topic: OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer

QR355 Virology
type: Concept