TY - JOUR N1 - Copyright of this article belongs to Informa Healthcare. ID - open262 UR - http://www.biotechniques.com/multimedia/archive/00009/02333st05_9075a.pdf IS - 3 A1 - Issac, Biju A1 - Raghava, G.P.S. Y1 - 2002/09// N2 - Similarity searches are a powerful method for solving important biological problems such as database scanning, evolutionary studies, gene prediction, and protein structure prediction. FASTA is a widely used sequence comparison tool for rapid database scanning. Here we describe the GWFASTA server that was developed to assist the FASTA user in similarity searches against partially and/or completely sequenced genomes. GWFASTA consists of more than 60 microbial genomes, eight eukaryote genomes, and proteomes of annotatedgenomes. Infact, it provides the maximum number of databases for similarity searching from a single platform. GWFASTA allows the submission of more than one sequence as a single query for a FASTA search. It also provides integrated post-processing of FASTA output, including compositional analysis of proteins, multiple sequences alignment, and phylogenetic analysis. Furthermore, it summarizes the search results organism-wise for prokaryotes and chromosome-wise for eukaryotes. Thus, the integration of different tools for sequence analyses makes GWFASTA a powerful toolfor biologists. PB - Informa healthcare/ Biotechniques.com JF - BioTechniques VL - 33 SN - 0736-6205 TI - GWFASTA: server for FASTA search in eukaryotic and microbial genomes. SP - 548 AV - restricted EP - 50, 552, 554 ER -