{
      "number": 1,
      "subjects": [
        "QR"
      ],
      "eprintid": 2648,
      "date": "2021-01-14",
      "userid": 2,
      "official_url": "https:\/\/iopscience.iop.org\/article\/10.1149\/1945-7111\/abd929\/meta",
      "rev_number": 7,
      "creators": [
        {
          "name": {
            "lineage": null,
            "given": "Ranjan Kumar",
            "honourific": null,
            "family": "Maurya"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "M.A.",
            "honourific": null,
            "family": "Alam"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Ahmed",
            "honourific": null,
            "family": "Nadeem"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Rahul",
            "honourific": null,
            "family": "Prajesh"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Megha",
            "honourific": null,
            "family": "Choudhury"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Vijayender",
            "honourific": null,
            "family": "Bhalla"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Ajay",
            "honourific": null,
            "family": "Agrawal"
          }
        }
      ],
      "dir": "disk0\/00\/00\/26\/48",
      "lastmod": "2021-02-01 04:18:00",
      "ispublished": "pub",
      "publisher": "IOP Science Publishing",
      "metadata_visibility": "show",
      "date_type": "published",
      "eprint_status": "archive",
      "status_changed": "2021-02-01 04:18:00",
      "volume": 168,
      "datestamp": "2021-02-01 04:18:00",
      "uri": "http:\/\/crdd.osdd.net\/open\/id\/eprint\/2648",
      "note": "The copyright of this article belongs to IOP Science Publishing.",
      "refereed": "TRUE",
      "contact_email": "kps@imtech.res.in",
      "publication": "Journal of the Electrochemical Society",
      "abstract": "A novel approach for signal enhancement of electrochemical biosensors by incorporating mechanical vibrations has been developed. We report the electrochemical study of the ferricyanide and ferrocyanide $\\left(\\,{\\left[{\\rm{Fe}}{\\left({\\rm{CN}}\\right)}_{6}\\right]}^{-3\/-4}\\right)$ a redox couple, at room temperature (~25 °C), under the effect of mechanical vibrations of different frequencies applied to the sensor, for sensitivity enhancement. The experimental results showed a sensitivity enhancement of ~332% (from $3.125\\,{\\rm{nA}}\\,\\mu {{\\rm{M}}}^{-1}$ to $13.5\\,{\\rm{nA}}\\,\\mu {{\\rm{M}}}^{-1}$) at 88.75 Hz of vibration. This novel approach of signal sensitivity enhancement is also validated with antibody immobilization-based Vi antigen detection for typhoid assessment. The sensitivity enhancement up to ~15% is achieved for Vi antigen detection under the mechanical vibration of 120 Hz. The sensor is fabricated using microfabrication technology. The vibration-assisted ultrasensitive biosensing platform is also prototyped as a portable and Internet of Thing (IoT) enabled device, suitable for point-of-care applications. Detailed features of the prototype along with the test results are elaborated in the paper.",
      "type": "article",
      "title": "Sensitivity Enhancement of Electrochemical Biosensor for Point of Care (POC) Applications: Vi Antigen Detection as a Case Study"
    }