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primary topic: Sensitivity Enhancement of Electrochemical Biosensor for Point of Care (POC) Applications: Vi Antigen Detection as a Case Study

Sensitivity Enhancement of Electrochemical Biosensor for Point of Care (POC) Applications: Vi Antigen Detection as a Case Study
type: AcademicArticle
type: Article
abstract: A novel approach for signal enhancement of electrochemical biosensors by incorporating mechanical vibrations has been developed. We report the electrochemical study of the ferricyanide and ferrocyanide $\left(\,{\left[{\rm{Fe}}{\left({\rm{CN}}\right)}_{6}\right]}^{-3/-4}\right)$ a redox couple, at room temperature (~25 °C), under the effect of mechanical vibrations of different frequencies applied to the sensor, for sensitivity enhancement. The experimental results showed a sensitivity enhancement of ~332% (from $3.125\,{\rm{nA}}\,\mu {{\rm{M}}}^{-1}$ to $13.5\,{\rm{nA}}\,\mu {{\rm{M}}}^{-1}$) at 88.75 Hz of vibration. This novel approach of signal sensitivity enhancement is also validated with antibody immobilization-based Vi antigen detection for typhoid assessment. The sensitivity enhancement up to ~15% is achieved for Vi antigen detection under the mechanical vibration of 120 Hz. The sensor is fabricated using microfabrication technology. The vibration-assisted ultrasensitive biosensing platform is also prototyped as a portable and Internet of Thing (IoT) enabled device, suitable for point-of-care applications. Detailed features of the prototype along with the test results are elaborated in the paper.
date: 2021-01-14
volume: 168
issue: 1
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

IOP Science Publishing
type: Organization

Journal of the Electrochemical Society
type: Collection

Vijayender Bhalla
type: Person
given name: Vijayender
family name: Bhalla

Ajay Agrawal
type: Person
given name: Ajay
family name: Agrawal

Rahul Prajesh
type: Person
given name: Rahul
family name: Prajesh

M.A. Alam
type: Person
given name: M.A.
family name: Alam

Megha Choudhury
type: Person
given name: Megha
family name: Choudhury

Ahmed Nadeem
type: Person
given name: Ahmed
family name: Nadeem

Ranjan Kumar Maurya
type: Person
given name: Ranjan Kumar
family name: Maurya

HTML Summary of #2648 Sensitivity Enhancement of Electrochemical Biosensor for Point of Care (POC) Applications: Vi Antigen Detection as a Case Study
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primary topic: Sensitivity Enhancement of Electrochemical Biosensor for Point of Care (POC) Applications: Vi Antigen Detection as a Case Study

QR Microbiology
type: Concept