<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice"^^ . "Regulatory T (T-reg) cells are essential to maintain immune homeostasis in the intestine and T-reg cell dysfunction is associated with several inflammatory and autoimmune disorders including inflammatory bowel disease (IBD). Efforts using low-dose (LD) interleukin-2 (IL-2) to expand autologous T-reg cells show therapeutic efficacy for several inflammatory conditions. Whether LD IL-2 is an effective strategy for treating patients with IBD is unknown. Recently, we demonstrated that LD IL-2 was protective against experimental colitis in immune humanized mice in which human CD4(+) T cells were restricted to human leukocyte antigen (HLA). Whether HLA restriction is required for human T-reg cells to ameliorate colitis following LD IL-2 therapy has not been demonstrated. Here, we show that treatment with LD IL-2 reduced 2,4,6-trinitrobenzensulfonic acid (TNBS) colitis severity in NOD.Prkdc(scid)Il2rg(-/-) (NSG) mice reconstituted with human CD34(+) hematopoietic stem cells. These data demonstrate the utility of standard immune humanized NSG mice as a pre-clinical model system to evaluate therapeutics targeting human T-reg cells to treat IBD."^^ . "2021-02-24" . "12" . . "Frontiers"^^ . . . "Frontiers in immunology"^^ . . . "16643224" . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Jing"^^ . "Li"^^ . "Jing Li"^^ . . "Justin"^^ . "Jacobse"^^ . "Justin Jacobse"^^ . . "K T"^^ . "Wilson"^^ . "K T Wilson"^^ . . "Kevin L."^^ . "Otipoby"^^ . "Kevin L. Otipoby"^^ . . "Rajeev K"^^ . "Tyagi"^^ . "Rajeev K Tyagi"^^ . . "Margret M."^^ . "Allaman"^^ . "Margret M. Allaman"^^ . . "Jeremy A."^^ . "Goettel"^^ . "Jeremy A. Goettel"^^ . . "Erik R."^^ . "Sampson"^^ . "Erik R. Sampson"^^ . . . . . "HTML Summary of #2660 \n\nHLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice\n\n" . "text/html" . . . "QR180 Immunology"@en . .