TY  - JOUR
N1  - The copyright of this article belongs to Elsevier Science.
ID  - open2668
UR  - https://www.sciencedirect.com/science/article/abs/pii/S1044579X20301437
A1  - Singh, Raghwendra Pratap
A1  - Bashir, Hilal
A1  - Kumar, Rashmi
Y1  - 2021/05/01/
N2  - Gut microbiota is emerging as a key modulator of the immune system. Alteration of gut microbiota impacts functioning of the immune system and pathophysiology of several diseases, including cancer. Growing evidence indicates that gut microbiota is not only involved in carcinogenesis but also has an impact on the efficacy and toxicity of cancer therapy. Recently, several pre-clinical and clinical studies across diverse cancer types reported the influence of gut microbiota on the host immune response to immunotherapy. Advancement in our understanding of the mechanism behind microbiota-mediated modulation of immune response is paramount for their utilization as cancer therapeutics. These microbial therapies in combination with conventional immunotherapeutic methods have the potential to transform the pre-existing treatment strategies to personalized cancer therapy. In this review, we have summarized the current status of research in the field and discussed the role of microbiota as an immune system modulator in context of cancer and their impact on immunotherapy.
PB  - Elsevier Science
JF  - Seminar in Cancer Biology
VL  - 70
KW  - Microbiome;Microbiota;Cancer; Immunotherapy;FMT;Probiotics
TI  - Emerging role of microbiota in immunomodulation and cancer immunotherapy
SP  - 37
EP  - 52
ER  -