creators_name: Singh, Raghwendra Pratap
creators_name: Bashir, Hilal
creators_name: Kumar, Rashmi
type: article
datestamp: 2021-04-26 06:19:42
lastmod: 2021-04-26 06:19:42
metadata_visibility: show
title: Emerging role of microbiota in immunomodulation and cancer immunotherapy
ispublished: pub
subjects: QR
keywords: Microbiome;Microbiota;Cancer; Immunotherapy;FMT;Probiotics
note: The copyright of this article belongs to Elsevier Science.
abstract: Gut microbiota is emerging as a key modulator of the immune system. Alteration of gut microbiota impacts functioning of the immune system and pathophysiology of several diseases, including cancer. Growing evidence indicates that gut microbiota is not only involved in carcinogenesis but also has an impact on the efficacy and toxicity of cancer therapy. Recently, several pre-clinical and clinical studies across diverse cancer types reported the influence of gut microbiota on the host immune response to immunotherapy. Advancement in our understanding of the mechanism behind microbiota-mediated modulation of immune response is paramount for their utilization as cancer therapeutics. These microbial therapies in combination with conventional immunotherapeutic methods have the potential to transform the pre-existing treatment strategies to personalized cancer therapy. In this review, we have summarized the current status of research in the field and discussed the role of microbiota as an immune system modulator in context of cancer and their impact on immunotherapy.
date: 2021-05-01
date_type: published
publication: Seminar in Cancer Biology
volume: 70
publisher: Elsevier Science
pagerange: 37-52
id_number: 10.1016/j.semcancer.2020.06.008
refereed: TRUE
official_url: https://www.sciencedirect.com/science/article/abs/pii/S1044579X20301437
citation:   Singh, Raghwendra Pratap and Bashir, Hilal and Kumar, Rashmi  (2021) Emerging role of microbiota in immunomodulation and cancer immunotherapy.  Seminar in Cancer Biology, 70.  pp. 37-52.