<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Efficient in vitro and in vivo docetaxel delivery mediated by pH-sensitive LPHNPs for effective breast cancer therapy"^^ . "The present study was designed to develop pH-sensitive lipid polymer hybrid nanoparticles (pHS-LPHNPs) for specific cytosolic-delivery of docetaxel (DTX). The pHS-LPHNPs-DTX formulation was prepared by self assembled nano-precipitation technique and characterized for zeta potential, particle size, entrapment efficiency, polydispersity index (PDI), and in vitro drug release. In vitro cytotoxicity of pHS-LPHNPs-DTX was assessed on breast cancer cells (MDA-MB-231 and MCF-7) and compared with DTX-loaded conventional LPHNPs and bare DTX. In vitro cellular uptake in MDA-MB-231 cell lines showed better uptake of pHS-LPHNPs. Further, a significant reduction in the IC50 of pHS-LPHNPs-DTX against both breast cancer cells was observed. Flow cytometry results showed greater apoptosis in case of pHS-LPHNPs-DTX treated MDA-MB-231 cells. Breast cancer was experimentally induced in BALB/c female mice, and the in vivo efficacy of the developed pHS-LPHNPs formulation was assessed with respect to the pharmacokinetics, biodistribution in the vital organs (liver, kidney, heart, lungs, and spleen), percentage tumor burden, and survival of breast cancer-bearing animals. In vivo studies showed improved pharmacokinetic and target-specificity with minimum DTX circulation in the deep-seated organs in the case of pHS-LPHNPs-DTX compared to the LPHNPs-DTX and free DTX. Mice treated with pHSLPHNPs-DTX exhibited a significantly lesser tumor burden than other treatment groups. Also, reduced distribution of DTX in the serum was evident for pHS-LPHNPs-DTX treated mice compared to the LPHNPs-DTX and free DTX. In essence, pHS-LPHNPs mediated delivery of DTX presents a viable platform for developing therapeutic-interventions against breast-cancer."^^ . "2021-07" . "203" . . "Elsevier Science/Academic Press"^^ . . . "COLLOIDS AND SURFACES B-BIOINTERFACES"^^ . . . "09277765" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Manoj"^^ . "Sharma"^^ . "Manoj Sharma"^^ . . "Ujjawal"^^ . "Sharma"^^ . "Ujjawal Sharma"^^ . . "Rajesh"^^ . "Salve"^^ . "Rajesh Salve"^^ . . "Kavita "^^ . "Gajbhiye"^^ . "Kavita Gajbhiye"^^ . . "Rajeev K"^^ . "Tyagi"^^ . "Rajeev K Tyagi"^^ . . "O P"^^ . "Katare"^^ . "O P Katare"^^ . . "Neeraj"^^ . "Garg"^^ . "Neeraj Garg"^^ . . "Nikunj"^^ . "Tandel"^^ . "Nikunj Tandel"^^ . . "Rajesh Singh"^^ . "Jadon"^^ . "Rajesh Singh Jadon"^^ . . "Gajanand"^^ . "Sharma"^^ . "Gajanand Sharma"^^ . . "Virendra"^^ . "Gajbhiye"^^ . "Virendra Gajbhiye"^^ . . . . . "HTML Summary of #2698 \n\nEfficient in vitro and in vivo docetaxel delivery mediated by pH-sensitive LPHNPs for effective breast cancer therapy\n\n" . "text/html" . . . "QR Microbiology"@en . .