@article{open271, volume = {22}, number = {1}, author = {C Raman Suri and Manoj Raje and Grish C Varshney}, note = {Copyright of this article belongs to Informa Healthcare.}, title = {Immunosensors for pesticide analysis: antibody production and sensor development.}, publisher = {Informa healthcare}, year = {2002}, journal = {Critical reviews in biotechnology}, pages = {15--32}, keywords = {immunosensor, antibody, immune-complex, pesticides.}, url = {http://crdd.osdd.net/open/271/}, abstract = {Immunosensors, a type of affinity biosensor, are based on the binding interactions between an immobilized biomolecule (antibody/antigen) on the electronic transducer surface with the analyte of interest (antigen/antibody), resulting in a detectable signal. The sensor system takes advantage of the high selectivity provided by the molecular recognition characteristic of an antibody, which binds reversibly with a specific antigen. This review article presents the current status of immunosensors, highlighting their potential benefits and limitations for pesticide analysis. The basic criteria for generating specific antibodies against low-molecular-mass pesticides, which are usually nonimmunogenic in nature, are briefly discussed. The article also describes the fundamentals of important transducer technologies and their use in immunosensor development.} }