<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Discerning the role of a functional arsenic- resistance cassette in the evolution and adaptation of a rice pathogen"^^ . "Arsenic is highly toxic element to all forms of life and is a major environmental contaminant. Understanding acquisition, detoxification and adaptation mechanisms in bacteria that are associated with the host in arsenic-rich conditions can provide novel insights into the evolutionary dynamics of host–microbe–environment interactions. In the present study, we have investigated an arsenic-resistance mechanism acquired during the evolution of a particular lineage in the population of Xanthomonas oryzae pv. oryzae, which is a serious plant pathogen infecting rice. Our study revealed the horizontal acquisition of a novel chromosomal 12 kb ars cassette in X. oryzae pv. oryzae IXO1088 that confers high resistance to arsenate/arsenite. The ars cassette comprises several genes that constitute an operon induced in the presence of arsenate/arsenite. Transfer of the cloned ars cassette to X. oryzae pv. oryzae BXO512, which lacks the cassette, confers an arsenic-resistance phenotype. Furthermore, the transcriptional response of X. oryzae pv. oryzae IXO1088 under arsenate/arsenite exposure was analysed using RNA sequencing. Arsenic detoxification and efflux, oxidative stress, iron acquisition/storage, and damage repair are the main cellular responses to arsenic exposure. Our investigation has provided insights into the existence of a novel detoxification and adaptation mechanism within the X. oryzae pv. oryzae population to deal with high-arsenic conditions outside the rice plant."^^ . "2021-07-13" . "7" . "7" . . "Microbiology Society"^^ . . . "MICROBIAL GENOMICS"^^ . . . . . . . . . . . . . . . . . "Tanu"^^ . "Saroha"^^ . "Tanu Saroha"^^ . . "Amandeep"^^ . "Kaur"^^ . "Amandeep Kaur"^^ . . "Prabhu B."^^ . "Patil"^^ . "Prabhu B. Patil"^^ . . "Rekha"^^ . "Rana"^^ . "Rekha Rana"^^ . . . . . "HTML Summary of #2712 \n\nDiscerning the role of a functional arsenic- resistance cassette in the evolution and adaptation of a rice pathogen\n\n" . "text/html" . . . "QR Microbiology"@en . .