creators_name: Negi, Sushmita
creators_name: Saini, Sheetal
creators_name: Tandel, Nikunj
creators_name: Sahu, Kiran
creators_name: Mishra, Ravi P. N.
creators_name: Tyagi, Rajeev K.
type: article
datestamp: 2022-03-28 08:41:43
lastmod: 2022-03-28 08:41:43
metadata_visibility: show
title: Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice
ispublished: pub
subjects: QR
keywords: humanized mice; inflammatory bowels disease; Crohn’s disease; ulcerative colitis; human immune system; regulatory T cells
note: Copyright of this article belongs to MDPI
abstract: Crohn's disease and ulcerative colitis, two major forms of inflammatory bowel disease (IBD) in humans, afflicted in genetically predisposed individuals due to dysregulated immune response directed against constituents of gut flora. The defective immune responses mounted against the regulatory mechanisms amplify and maintain the IBD-induced mucosal inflammation. Therefore, restoring the balance between inflammatory and anti-inflammatory immunepathways in the gut may contribute to halting the IBD-associated tissue-damaging immune response. Phenotypic and functional characterization of various immune-suppressive T cells (regulatory T cells; Tregs) over the last decade has been used to optimize the procedures for in vitro expansion of these cells for developing therapeutic interventional strategies. In this paper, we review the mechanisms of action and functional importance of Tregs during the pathogenesis of IBD and modulating the disease induced inflammation as well as role of mouse models including humanized mice repopulated with the human immune system (HIS) to study the IBD. "Humanized" mouse models provide new tools to analyze human Treg ontogeny, immunobiology, and therapy and the role of Tregs in developing interventional strategies against IBD. Overall, humanized mouse models replicate the human conditions and prove a viable tool to study molecular functions of human Tregs to harness their therapeutic potential.
date: 2021-07-21
date_type: published
publication: CELLS
volume: 10
number: 8
publisher: MDPI
refereed: TRUE
official_url: https://www.mdpi.com/2073-4409/10/8/1847
citation:   Negi, Sushmita and Saini, Sheetal and Tandel, Nikunj and Sahu, Kiran and Mishra, Ravi P. N. and Tyagi, Rajeev K.  (2021) Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice.  CELLS, 10 (8).