creators_name: Chaudhary, Surbhi
creators_name: Dhiman, Asmita
creators_name: Patidar, Anil
creators_name: Malhotra, Himanshu
creators_name: Talukdar, Sharmila
creators_name: Dilawari, Rahul
creators_name: Chaubey, Gaurav Kumar
creators_name: Modanwal, Radheshyam
creators_name: Raje, Chaaya Iyengar
creators_name: Raje, Manoj
type: article
datestamp: 2022-03-28 11:48:00
lastmod: 2022-03-28 11:48:00
metadata_visibility: show
title: Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) modulates protein aggregation
ispublished: pub
subjects: QR
keywords: GAPDHHuntingtin; PrionAggregate; Multifunctional protein; Protein misfolding; 
note: The Copyright of this article belongs to ELSEVIER
abstract: Onset of protein aggregation reflects failure of the cellular folding machinery to keep aggregation-prone protein from misfolding and accumulating into a non-degradable state. FRET based analysis and biochemical data reveal that cytosolic prion (cyPrP) and httQ-103 interact with the multifunctional protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) leading to few detectable aggregates in GAPDH-over expressing cells.The preventive effect of GAPDH suggests that this abundant and long-lived cytoplasmic protein has an active role in the shielding and maintenance, in soluble form of proteins as heterogeneous as huntingtin and cyPrP.
date: 2021-10-01
date_type: published
publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
volume: 1867
number: 10
publisher: Elsevier
refereed: TRUE
official_url: https://www.sciencedirect.com/science/article/abs/pii/S0925443921001356
citation:   Chaudhary, Surbhi and Dhiman, Asmita and Patidar, Anil and Malhotra, Himanshu and Talukdar, Sharmila and Dilawari, Rahul and Chaubey, Gaurav Kumar and Modanwal, Radheshyam and Raje, Chaaya Iyengar and Raje, Manoj  (2021) Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) modulates protein aggregation.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1867 (10).