%0 Journal Article %@ 1472-6807 %A Agrawal, Vishal %A Kishan, R K %D 2001 %F open:279 %I Biomedcentral %J BMC structural biology %P 5 %T Functional evolution of two subtly different (similar) folds. %U http://crdd.osdd.net/open/279/ %V 1 %X The function of Oligonucleotide/oligosaccharide-binding (OB) fold proteins was restricted to either DNA/RNA binding or sugar binding whereas the Src homology 3 (SH3) domain like proteins bind to a variety of ligands through loop modulations. A question was raised whether the evolution of these two folds was through DNA shuffling. %Z OPEN ACCESS