creators_name: Mittal, J
creators_name: Dogra, N
creators_name: Vohra, H
creators_name: Majumdar, S
type: article
datestamp: 2012-01-05 15:16:31
lastmod: 2012-01-05 15:16:31
metadata_visibility: show
title: Effects of prostaglandin E2 and nitric oxide inhibitors on the expression of interleukin-10, interleukin-12 and MHC class-II molecules in Mycobacterium microti-infected and interferon-gamma-treated mouse peritoneal macrophages.
ispublished: pub
subjects: QR
full_text_status: restricted
note: Copyright of this article belongs to Springer Science.
abstract: Mycobacterium microti-infected mouse peritoneal macrophages produced high amounts of prostaglandin E2 (PGE2) and nitric oxide (NO) when activated with interferon-gamma (IFN-gamma). In order to understand the relation between PGE2 and NO production and the expression of interleukin-12 (IL-12), interleukin-10 (IL-10) and MHC class-II (Ia) molecules by M. microti-infected and IFN-gamma-stimulated macrophages, we analyzed the level of these molecules in the presence or absence of PGE2 and NO inhibitors. Addition of NG-methyl-L-arginine (L-NMA) and indomethacin (IM) caused a significant increase in IL-12 level (2.6- and 1.9-fold, respectively) whereas IL-10 level decreased by 88 and 56%, respectively, relative to M. microti-infected and IFN-gamma-treated control macrophages. Enhanced PGE2 and NO upregulated IL-10 expression and down-regulated IL-12 and MHC class-II (Ia) expression in M. microti-infected and IFN-gamma-treated mouse peritoneal macrophages.
date: 2001
date_type: published
publication: Folia microbiologica
volume: 46
number: 3
publisher: Springer Science
pagerange: 259-64
refereed: TRUE
issn: 0015-5632
official_url: http://www.springerlink.com/content/q31p563p68131087/fulltext.pdf
related_url_url: http://www.springerlink.com/content/q31p563p68131087/fulltext.pdf
related_url_type: pub
citation:   Mittal, J and Dogra, N and Vohra, H and Majumdar, S  (2001) Effects of prostaglandin E2 and nitric oxide inhibitors on the expression of interleukin-10, interleukin-12 and MHC class-II molecules in Mycobacterium microti-infected and interferon-gamma-treated mouse peritoneal macrophages.  Folia microbiologica, 46 (3).  pp. 259-64.  ISSN 0015-5632     
document_url: http://crdd.osdd.net/open/283/1/majumdar2001.pdf