creators_name: Kalra, Rashi
creators_name: Tiwari, Drishti
creators_name: Dkhar, H Kitdorlang
creators_name: Bhagyaraj, Ella
creators_name: Kumar, Rakesh
creators_name: Bhardwaj, Anshu
creators_name: Gupta, Pawan
type: article
datestamp: 2022-04-18 06:05:48
lastmod: 2022-04-18 06:05:48
metadata_visibility: show
title: Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy
ispublished: pub
subjects: QR
keywords: Host directed therapy (HDT); host epigenetic machinery; host transcription factors (TFs); host-pathogen interaction; tuberculosis (TB)
note: The Copyright of this article belongs to Informa healthcare
abstract: Despite new approaches in the diagnosis and treatment of tuberculosis (TB), it continues to be a major health burden. Several immunotherapies that potentiate the immune response have come up as adjuncts to drug therapies against drug resistant TB strains; however, there needs to be an urgent appraisal of host specific drug targets for improving their clinical management and to curtail disease progression. Presently, various host directed therapies (HDTs) exist (repurposed drugs, nutraceuticals, monoclonal antibodies and immunomodulatory agents), but these mostly address molecules that combat disease progression.
date: 2021-09-22
date_type: published
publication: International reviews of immunology
publisher: Informa healthcare
refereed: TRUE
issn: 1563-5244
official_url: https://www.tandfonline.com/doi/abs/10.1080/08830185.2021.1990277?journalCode=iiri20
citation:   Kalra, Rashi and Tiwari, Drishti and Dkhar, H Kitdorlang and Bhagyaraj, Ella and Kumar, Rakesh and Bhardwaj, Anshu and Gupta, Pawan  (2021) Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy.  International reviews of immunology.   ISSN 1563-5244