@article{open2977,
          volume = {59},
          number = {5},
           month = {May},
          author = {Aikan  Gupta and Yogesh  Sharma and Ganesh P.  Pawar and Ashish Ashish  and D Nihalani and Vinod Chaudhari},
            note = {The copyright of this article belongs to Wiley 
},
           title = {An efficient and scalable synthesis of Isodesmosine},
       publisher = {Wiley},
            year = {2022},
         journal = {Journal of Heterocyclic Chemistry},
           pages = {958--963},
             url = {http://crdd.osdd.net/open/2977/},
        abstract = {Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.}
}