title: An efficient and scalable synthesis of Isodesmosine
creator: Gupta, Aikan 
creator: Sharma, Yogesh 
creator: Pawar, Ganesh P. 
creator: Ashish , Ashish
creator: Nihalani, D
creator: Chaudhari, Vinod
subject: QR Microbiology
description: Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
publisher: Wiley
date: 2022-05
type: Article
type: PeerReviewed
relation: https://onlinelibrary.wiley.com/doi/10.1002/jhet.4441
identifier:   Gupta, Aikan  and Sharma, Yogesh  and Pawar, Ganesh P.  and Ashish , Ashish and Nihalani, D and Chaudhari, Vinod  (2022) An efficient and scalable synthesis of Isodesmosine.  Journal of Heterocyclic Chemistry, 59 (5).  pp. 958-963.      
relation: http://crdd.osdd.net/open/2977/