%0 Journal Article
%A Gupta, Aikan 
%A Sharma, Yogesh 
%A Pawar, Ganesh P. 
%A Ashish , Ashish
%A Nihalani, D
%A Chaudhari, Vinod
%D 2022
%F open:2977
%I Wiley
%J Journal of Heterocyclic Chemistry
%N 5
%P 958-963
%T An efficient and scalable synthesis of Isodesmosine
%U http://crdd.osdd.net/open/2977/
%V 59
%X Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
%Z The copyright of this article belongs to Wiley