TY  - JOUR
N1  - The copyright of this article belongs to Wiley 

ID  - open2977
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jhet.4441
IS  - 5
A1  - Gupta, Aikan 
A1  - Sharma, Yogesh 
A1  - Pawar, Ganesh P. 
A1  - Ashish , Ashish
A1  - Nihalani, D
A1  - Chaudhari, Vinod
Y1  - 2022/05//
N2  - Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
PB  - Wiley
JF  - Journal of Heterocyclic Chemistry
VL  - 59
TI  - An efficient and scalable synthesis of Isodesmosine
SP  - 958
EP  - 963
ER  -