%A Aikan  Gupta
%A Yogesh  Sharma
%A Ganesh P.  Pawar
%A Ashish Ashish 
%A D Nihalani
%A Vinod Chaudhari
%O The copyright of this article belongs to Wiley 

%J Journal of Heterocyclic Chemistry
%T An efficient and scalable synthesis of Isodesmosine
%X Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
%N 5
%P 958-963
%V 59
%D 2022
%I Wiley
%L open2977