creators_name: Gupta, Aikan 
creators_name: Sharma, Yogesh 
creators_name: Pawar, Ganesh P. 
creators_name: Ashish , Ashish
creators_name: Nihalani, D
creators_name: Chaudhari, Vinod
type: article
datestamp: 2022-07-22 04:27:51
lastmod: 2022-07-22 04:27:51
metadata_visibility: show
title: An efficient and scalable synthesis of Isodesmosine
ispublished: pub
subjects: QR
note: The copyright of this article belongs to Wiley 

abstract: Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
date: 2022-05
date_type: published
publication: Journal of Heterocyclic Chemistry
volume: 59
number: 5
publisher: Wiley
pagerange: 958-963
refereed: TRUE
official_url: https://onlinelibrary.wiley.com/doi/10.1002/jhet.4441
citation:   Gupta, Aikan  and Sharma, Yogesh  and Pawar, Ganesh P.  and Ashish , Ashish and Nihalani, D and Chaudhari, Vinod  (2022) An efficient and scalable synthesis of Isodesmosine.  Journal of Heterocyclic Chemistry, 59 (5).  pp. 958-963.