<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "A comparative study of in-vitro and in-silico anti-candidal activity and GC-MS profiles of snow mountain garlic vs. normal garlic"^^ . "Aim: The study aimed to profile the volatile phytocomposition of snow mountain garlic (SMG) compared to normal garlic and investigate the anti-Candida efficacy against clinically relevant multi-drug resistant isolates of Candida species.\r\n\r\nMethods and results: Herein, SMG has shown significantly superior fungicidal power at 2x-MIC dose against C. albicans and C. glabrata in killing kinetic evaluation unlike the fungistatic effect of normal garlic. GC-MS headspace-based profiling of SMG showed 5 unique volatile compounds and a 5-fold higher content of saponins than normal garlic. In an in-silico analysis, cholesta-4,6-dien-3-ol,(3-beta) was uniquely identified in SMG as a potential inhibitor with high binding affinity to the active site of exo-1,3-betaglucan synthase, an established anti-candida drug target crucial for the biofilm matrix formation, thus suggesting a plausible anti-Candida mechanism.\r\n\r\nConclusion: The in-vitro and in-silico studies have demonstrated the Candida-cidal and anti-biofilm activities of SMG, distinguishing it from the Candida-static efficacy of normal garlic."^^ . "2022-04-07" . . "Wiley"^^ . . . "Journal of applied microbiology"^^ . . . "13645072" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Manoj K "^^ . "Patel"^^ . "Manoj K Patel"^^ . . "Shweta "^^ . "Saxena"^^ . "Shweta Saxena"^^ . . "Nitish "^^ . "Kumar"^^ . "Nitish Kumar"^^ . . "Om Prakash "^^ . "Chaurasia"^^ . "Om Prakash Chaurasia"^^ . . "Deepika "^^ . "Sharma"^^ . "Deepika Sharma"^^ . . "Rajni "^^ . "Sharma"^^ . "Rajni Sharma"^^ . . "Sonam "^^ . "Chawla"^^ . "Sonam Chawla"^^ . . "Kanwaljit "^^ . "Chopra"^^ . "Kanwaljit Chopra"^^ . . "Bhupinder "^^ . "Kaur "^^ . "Bhupinder Kaur "^^ . . "Suresh "^^ . "Korpole "^^ . "Suresh Korpole "^^ . . . . . "HTML Summary of #2979 \n\nA comparative study of in-vitro and in-silico anti-candidal activity and GC-MS profiles of snow mountain garlic vs. normal garlic\n\n" . "text/html" . . . "QR Microbiology"@en . .