title: Swertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei
creator: Patel, Naisargee 
creator: Zinzuvadia, Aarushi 
creator: Prajapat, Mitali 
creator: Tyagi, Rajeev K
creator: Dalai, Sarat
subject: QR Microbiology
description: Aims: Development of resistance by the malaria parasite, a systemic inflammatory and infectious pathogen, has raised the need for novel efficacious antimalarials. Plant-derived natural compounds are known to modulate the immune response and eradicate the infectious pathogens. Therefore we carried out experiments with swertiamarin to dissect its anti-inflammatory and immunomodulatory potential. Materials & methods: We carried out studies in Swiss albino mice that received infectious challenge with Plasmodium berghei and swertiamarin treatment in a prophylactic manner. Results & conclusion: Oral administration of swertiamarin prior to infectious challenge with P. berghei in experimental mice showed delayed parasite development as compared with untreated control. IFN-γ and IL-10 appeared to be adapted/modulated by regular swertiamarin treatment. Further, withdrawal of swertiamarin pressure did not affect parasite replication. However, the short half-life of swertiamarin limited its long-lasting therapeutic effect, requiring higher and frequent dosing schedules.
publisher: Future Medicine 
date: 2022-06-15
type: Article
type: PeerReviewed
relation: https://www.futuremedicine.com/doi/10.2217/fmb-2021-0298?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
identifier:   Patel, Naisargee  and Zinzuvadia, Aarushi  and Prajapat, Mitali  and Tyagi, Rajeev K and Dalai, Sarat  (2022) Swertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei.  Future Microbiology .       
relation: http://crdd.osdd.net/open/2988/