<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Swertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei"^^ . "Aims: Development of resistance by the malaria parasite, a systemic inflammatory and infectious pathogen, has raised the need for novel efficacious antimalarials. Plant-derived natural compounds are known to modulate the immune response and eradicate the infectious pathogens. Therefore we carried out experiments with swertiamarin to dissect its anti-inflammatory and immunomodulatory potential. Materials & methods: We carried out studies in Swiss albino mice that received infectious challenge with Plasmodium berghei and swertiamarin treatment in a prophylactic manner. Results & conclusion: Oral administration of swertiamarin prior to infectious challenge with P. berghei in experimental mice showed delayed parasite development as compared with untreated control. IFN-γ and IL-10 appeared to be adapted/modulated by regular swertiamarin treatment. Further, withdrawal of swertiamarin pressure did not affect parasite replication. However, the short half-life of swertiamarin limited its long-lasting therapeutic effect, requiring higher and frequent dosing schedules."^^ . "2022-06-15" . . "Future Medicine "^^ . . . "Future Microbiology "^^ . . . . . . . . . . . . . . . . . . . . "Rajeev K"^^ . "Tyagi"^^ . "Rajeev K Tyagi"^^ . . "Aarushi "^^ . "Zinzuvadia"^^ . "Aarushi Zinzuvadia"^^ . . "Sarat"^^ . "Dalai"^^ . "Sarat Dalai"^^ . . "Mitali "^^ . "Prajapat"^^ . "Mitali Prajapat"^^ . . "Naisargee "^^ . "Patel"^^ . "Naisargee Patel"^^ . . . . . "HTML Summary of #2988 \n\nSwertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei\n\n" . "text/html" . . . "QR Microbiology"@en . .