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primary topic: Host glyceraldehyde-3-phosphate dehydrogenase-mediated iron acquisition is hijacked by intraphagosomal Mycobacterium tuberculosis

Host glyceraldehyde-3-phosphate dehydrogenase-mediated iron acquisition is hijacked by intraphagosomal Mycobacterium tuberculosis
type: AcademicArticle
type: Article
abstract: Availability of iron is a key factor in the survival and multiplication of Mycobacterium tuberculosis (M.tb) within host macrophage phagosomes. Despite host cell iron regulatory machineries attempts to deny supply of this essential micronutrient, intraphagosomal M.tb continues to access extracellular iron. In the current study, we report that intracellular M.tb exploits mammalian secreted Glyceraldehyde 3-phosphate dehydrogenase (sGAPDH) for the delivery of host iron carrier proteins lactoferrin (Lf) and transferrin (Tf). Studying the trafficking of iron carriers in infected cells we observed that sGAPDH along with the iron carrier proteins are preferentially internalized into infected cells and trafficked to M.tb containing phagosomes where they are internalized by resident mycobacteria resulting in iron delivery. Collectively our findings provide a new mechanism of iron acquisition by M.tb involving the hijack of host sGAPDH. This may contribute to its successful pathogenesis and provide an option for targeted therapeutic intervention.
date: 2022
volume: 79
issue: 1
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Springer
type: Organization

Cellular and Molecular Life Sciences
type: Collection

Manoj Raje
type: Person
given name: Manoj
family name: Raje

Anil Patidar
type: Person
given name: Anil
family name: Patidar

Asmita Dhiman
type: Person
given name: Asmita
family name: Dhiman

Gaurav Kumar Chaubey
type: Person
given name: Gaurav Kumar
family name: Chaubey

Surbhi Chaudhary
type: Person
given name: Surbhi
family name: Chaudhary

Himanshu Malhotra
type: Person
given name: Himanshu
family name: Malhotra

Sharmila Talukdar
type: Person
given name: Sharmila
family name: Talukdar

Chaaya Iyengar Raje
type: Person
given name: Chaaya Iyengar
family name: Raje

Manoj Kumar
type: Person
given name: Manoj
family name: Kumar

Rahul Dilawari
type: Person
given name: Rahul
family name: Dilawari

Radheshyam Modanwal
type: Person
given name: Radheshyam
family name: Modanwal

HTML Summary of #2989 Host glyceraldehyde-3-phosphate dehydrogenase-mediated iron acquisition is hijacked by intraphagosomal Mycobacterium tuberculosis
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primary topic: Host glyceraldehyde-3-phosphate dehydrogenase-mediated iron acquisition is hijacked by intraphagosomal Mycobacterium tuberculosis

QR Microbiology
type: Concept