creators_name: Saroha, Tanu 
creators_name: Chaudhry, Vasvi 
creators_name: Patil , Prabhu B 
type: article
datestamp: 2022-07-25 06:07:45
lastmod: 2022-07-25 06:07:45
metadata_visibility: show
title: Novel insights into the role of the mobilome in ecological diversification and success of Staphylococcus haemolyticus as an opportunistic pathogen
ispublished: pub
subjects: QR
keywords: IS element; Staphylococcus haemolyticus; complete genome; mobile elements; plant host; plasmids
note: The copyright of this article belongs to MICROBIOLOGY SOCIETY 
abstract: Staphylococcus haemolyticus is a species of coagulase-negative staphylococci that has primarily been studied as a human skin microbiome member and an emerging nosocomial pathogen. Here, we present the first complete genome of S. haemolyticus strains SE3.9, SE3.8 and SE2.14 reported as an endophyte of rice seed. Detailed investigation of the genome dynamics of strains from diverse origins revealed an expanded genome size in clinical isolates, and a role of many insertion sequence (IS) elements in strain diversification. Interestingly, several of the IS elements are also unique or enriched in a particular habitat. Comparative studies also revealed the potential movement of mobile elements from rice endophytic S. haemolyticus to strains from other pathogenic species such as Staphylococcus aureus. The study highlights the importance of ecological studies in the systematic understanding of genome plasticity and management of medically important Staphylococcus species.
date: 2022-01-24
date_type: published
publication: Microbial Genomics 
volume: 8
number: 1
publisher: MICROBIOLOGY SOCIETY 
refereed: TRUE
official_url: https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000755#tab2
citation:   Saroha, Tanu  and Chaudhry, Vasvi  and Patil , Prabhu B   (2022) Novel insights into the role of the mobilome in ecological diversification and success of Staphylococcus haemolyticus as an opportunistic pathogen.  Microbial Genomics , 8 (1).