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primary topic: NKB cells: A double-edged sword against inflammatory diseases

NKB cells: A double-edged sword against inflammatory diseases
type: AcademicArticle
type: Article
abstract: Interferon-γ (IFN-γ)-producing natural killer (NK) cells and innate lymphoid cells (ILCs) activate the adaptive system's B and T cells in response to pathogenic invasion; however, how these cells are activated during infections is not yet fully understood. In recent years, a new lymphocyte population referred to as "natural killer-like B (NKB) cells", expressing the characteristic markers of innate NK cells and adaptive B cells, has been identified in both the spleen and mesenteric lymph nodes during infectious and inflammatory pathologies. NKB cells produce IL-18 and IL-12 cytokines during the early phases of microbial infection, differentiating them from conventional NK and B cells. Emerging evidence indicates that NKB cells play key roles in clearing microbial infections. In addition, NKB cells contribute to inflammatory responses during infectious and inflammatory diseases. Hence, the role of NKB cells in disease pathogenesis merits further study. An in-depth understanding of the phenotypic, effector, and functional properties of NKB cells may pave the way for the development of improved vaccines and therapeutics for infectious and inflammatory diseases.
date: 2022-11
volume: 13
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Frontiers
type: Organization

FRONTIERS IN IMMUNOLOGY
type: Collection

Rajeev K. Tyagi
type: Person
given name: Rajeev K.
family name: Tyagi

Nikunj Tandel
type: Person
given name: Nikunj
family name: Tandel

Sushmita Negi
type: Person
given name: Sushmita
family name: Negi

HTML Summary of #3026 NKB cells: A double-edged sword against inflammatory diseases
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primary topic: NKB cells: A double-edged sword against inflammatory diseases

QR Microbiology
type: Concept