creators_name: Tandel, Nikunj
creators_name: Negi, Sushmita
creators_name: Tyagi, Rajeev K.
type: article
datestamp: 2022-12-15 05:05:35
lastmod: 2022-12-15 05:05:35
metadata_visibility: show
title: NKB cells: A double-edged sword against inflammatory diseases
ispublished: pub
subjects: QR
keywords: IFN-γ; IL-12; IL-18; NKB cells; Th1 cells; infectious diseases; inflammation; innate lymphoid cells.
note: Copyright of this article belongs to Frontiers 
abstract: Interferon-γ (IFN-γ)-producing natural killer (NK) cells and innate lymphoid cells (ILCs) activate the adaptive system's B and T cells in response to pathogenic invasion; however, how these cells are activated during infections is not yet fully understood. In recent years, a new lymphocyte population referred to as "natural killer-like B (NKB) cells", expressing the characteristic markers of innate NK cells and adaptive B cells, has been identified in both the spleen and mesenteric lymph nodes during infectious and inflammatory pathologies. NKB cells produce IL-18 and IL-12 cytokines during the early phases of microbial infection, differentiating them from conventional NK and B cells. Emerging evidence indicates that NKB cells play key roles in clearing microbial infections. In addition, NKB cells contribute to inflammatory responses during infectious and inflammatory diseases. Hence, the role of NKB cells in disease pathogenesis merits further study. An in-depth understanding of the phenotypic, effector, and functional properties of NKB cells may pave the way for the development of improved vaccines and therapeutics for infectious and inflammatory diseases.
date: 2022-11
date_type: published
publication: FRONTIERS IN IMMUNOLOGY
volume: 13
publisher: Frontiers
refereed: TRUE
official_url: https://www.frontiersin.org/articles/10.3389/fimmu.2022.972435/full
citation:   Tandel, Nikunj and Negi, Sushmita and Tyagi, Rajeev K.  (2022) NKB cells: A double-edged sword against inflammatory diseases.  FRONTIERS IN IMMUNOLOGY, 13.