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primary topic: The opportunistic nature of gut commensal microbiota

The opportunistic nature of gut commensal microbiota
type: AcademicArticle
type: Article
abstract: The abundance of gut commensals has historically been associated with health-promoting effects despite the fact that the definition of good or bad microbiota remains condition-specific. The beneficial or pathogenic nature of microbiota is generally dictated by the dimensions of host-microbiota and microbe-microbe interactions. With the increasing popularity of gut microbiota in human health and disease, emerging evidence suggests opportunistic infections promoted by those gut bacteria that are generally considered beneficial. Therefore, the current review deals with the opportunistic nature of the gut commensals and aims to summarise the concepts behind the occasional commensal-to-pathogenic transformation of the gut microbes. Specifically, relevant clinical and experimental studies have been discussed on the overgrowth and bacteraemia caused by commensals. Three key processes and their underlying mechanisms have been summarised to be responsible for the opportunistic nature of commensals, viz. improved colonisation fitness that is dictated by commensal-pathogen interactions and availability of preferred nutrients; pathoadaptive mutations that can trigger the commensal-to-pathogen transformation; and evasion of host immune response as a survival and proliferation strategy of the microbes. Collectively, this review provides an updated concept summary on the underlying mechanisms of disease causative events driven by gut commensal bacteria.
date: 2022-10-18
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Taylor and Francis Online
type: Organization

CRITICAL REVIEWS IN MICROBIOLOGY
type: Collection

Saumya Ray Chaudhuri
type: Person
given name: Saumya Ray
family name: Chaudhuri

Priyankar Dey
type: Person
given name: Priyankar
family name: Dey

HTML Summary of #3027 The opportunistic nature of gut commensal microbiota
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primary topic: The opportunistic nature of gut commensal microbiota

QR Microbiology
type: Concept