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primary topic: Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant

Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant
type: AcademicArticle
type: Article
abstract: Background: Emergence of new variant of SARS-CoV-2, namely omicron, has posed a global concern because of its high rate of transmissibility and mutations in its genome. Researchers worldwide are trying to understand the evolution and emergence of such variants to understand the mutational cascade events. Methods: We have considered all omicron genomes (n = 302 genomes) available till 2nd December 2021 in the public repository of GISAID along with representatives of variants of concern (VOC), i.e., alpha, beta, gamma, delta, and omicron; variant of interest (VOI) mu and lambda; and variant under monitoring (VUM). Whole genome-based phylogeny and mutational analysis were performed to understand the evolution of SARS CoV-2 leading to emergence of omicron variant. Results: Whole genome-based phylogeny depicted two phylogroups (PG-I and PG-II) forming variant specific clades except for gamma and VUM GH. Mutational analysis detected 18,261 mutations in the omicron variant, majority of which were non-synonymous mutations in spike (A67, T547K, D614G, H655Y, N679K, P681H, D796Y, N856K, Q954H), followed by RNA dependent RNA polymerase (rdrp) (A1892T, I189V, P314L, K38R, T492I, V57V), ORF6 (M19M) and nucleocapsid protein (RG203KR). Conclusion: Delta and omicron have evolutionary diverged into distinct phylogroups and do not share a common ancestry. While, omicron shares common ancestry with VOI lambda and its evolution is mainly derived by the non-synonymous mutations.
date: 2022-07-02
volume: 315
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Elsevier
type: Organization

VIRUS RESEARCH
type: Collection

Sanjeet Kumar
type: Person
given name: Sanjeet
family name: Kumar

Kanika Bansal
type: Person
given name: Kanika
family name: Bansal

HTML Summary of #3046 Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant
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primary topic: Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant

QR Microbiology
type: Concept