@article{open3082, volume = {12}, number = {3}, month = {March}, author = { Harry Garg and Rajesh P. Ringe and Supankar Das and Suraj Parkash and Bhuwaneshwar Thakur and Rathina Delipan and Ajay Kumar and Kishore Kulkarni and Kanika Bansal and Prabhu B Patil and Tabish Alam and Babu Nagesh Balam and Chandan Swaroop Meena and Krishan Gopal Thakur and Ashok Kumar and Ashwani Kumar}, note = {The copyright of this article belongs to MDPI AG }, title = {UVC-Based Air Disinfection Systems for Rapid Inactivation of SARS-CoV-2 Present in the Air.}, publisher = {MDPI AG}, year = {2023}, journal = {Pathogens}, keywords = {COVID-19; SARS-CoV-2; UVC; aerosols; disinfection }, url = {http://crdd.osdd.net/open/3082/}, abstract = {The World Health Organization (WHO) declared in May 2021 that SARS-CoV-2 is transmitted not only by close contact with infectious respiratory fluids from infected people or contaminated materials but also indirectly through air. Airborne transmission has serious implications for the control measures we can deploy, given the emergence of more transmissible variants. This emphasizes the need to deploy a mechanism to reduce the viral load in the air, especially in closed and crowded places such as hospitals, public transport buses, etc. In this study, we explored ultraviolet C (UVC) radiation for its ability to inactivate the SARS-CoV-2 particles present in aerosols and designed an air disinfection system to eliminate infectious viruses. We studied the virus inactivation kinetics to identify the UVC dosage required to achieve maximum virus inactivation. Based on the experimental data, UVC-based devices were designed for the sanitization of air through HVAC systems in closed spaces. Further, a risk assessment model to estimate the risk reduction was applied which showed that the use of UVC radiation could result in the reduction of the risk of infection in occupied spaces by up to 90\%. } }