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primary topic: Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis

Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis
type: AcademicArticle
type: Article
abstract: Genetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant variant clade of SARS-CoV-2, using the data available on the Nextstrain server. We selected various mutations, namely, A222V, N439K, N501Y, L452R, Y453F, E484K, K417N, T478K, L981F, L212I, N856K, T547K, G496S, and Y369C for this study. These mutations were chosen based on their global entropic score, emergence, spread, transmission, and their location in the spike receptor binding domain (RBD). The relative abundance of these mutations was mapped with global mutation D614G as a reference. Our analyses suggest the rapid emergence of newer global mutations alongside D614G, as reported during the recent waves of COVID-19 in various parts of the world. These mutations could be instrumentally imperative for the transmission, infectivity, virulence, and host immune system's evasion of SARS-CoV-2. The probable impact of these mutations on vaccine effectiveness, antigenic diversity, antibody interactions, protein stability, RBD flexibility, and accessibility to human cell receptor ACE2 was studied in silico. Overall, the present study can help researchers to design the next generation of vaccines and biotherapeutics to combat COVID-19 infection.
date: 2023-03-27
volume: 15
issue: 4
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

MDPI
type: Organization

Viruses Basel
type: Collection

Yogesh Srivastava
type: Person
given name: Yogesh
family name: Srivastava

Geetika Verma
type: Person
given name: Geetika
family name: Verma

Ramachandra Abhishek Panigrahi
type: Person
given name: Ramachandra Abhishek
family name: Panigrahi

Hyunsuk Shin
type: Person
given name: Hyunsuk
family name: Shin

Kumar Dinesh Prajapati
type: Person
given name: Kumar Dinesh
family name: Prajapati

Savitri Tiwari
type: Person
given name: Savitri
family name: Tiwari

Rajeev K Tyagi
type: Person
given name: Rajeev K
family name: Tyagi

Reetesh Kumar
type: Person
given name: Reetesh
family name: Kumar

Kumar Samir Beura
type: Person
given name: Kumar Samir
family name: Beura

Kumar Pankaj Rai
type: Person
given name: Kumar Pankaj
family name: Rai

Prakriti Sharma
type: Person
given name: Prakriti
family name: Sharma

Pandiyan Muthuramalingam
type: Person
given name: Pandiyan
family name: Muthuramalingam

Nikunj Tandel
type: Person
given name: Nikunj
family name: Tandel

Somnath Maji
type: Person
given name: Somnath
family name: Maji

Kumar Sunil Singh
type: Person
given name: Kumar Sunil
family name: Singh

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primary topic: Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis

QR Microbiology
type: Concept