<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Studies on a new antimicrobial peptide from Vibrio proteolyticus MT110"^^ . "The marine environment is known for its vast diversity of the microbial population; however, less explored for bioactive compounds. In this study, an AMP produced by a new marine isolate, Vibrio proteolyticus MT110, showed broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. The AMP was purified to homogeneity using ethyl acetate extraction followed by RP-HPLC, and LC-MS analysis showed its molecular weight as 980 Da. The MIC of AMP (peptide-MT110) was obtained in the 7.81-31.25 µg/mL range against different indicator strains. Peptide-MT110 showed stability of its antimicrobial activity at 15-121 °C and pH 4-10 and in the presence of various hydrolytic enzymes. The peaks at 1536 cm-1 and 1712 cm-1 wavenumbers in FTIR spectra confirmed the peptidic nature of AMP, and its amino acid analysis confirmed the presence of tyrosine and isoleucine. The antibacterial activity of peptide-MT110 is confirmed by PI assay and TEM. The optimization of peptide-MT110 production using statistical methods resulted in a 2.64-fold higher production. The physicochemical properties and stability in wide pH and temperature ranges showed the potential of peptide-MT110 for its development as a drug candidate. This is believed to be the first report on an AMP from Vibrio proteolyticus."^^ . "2024-02" . "54" . "2" . . "TAYLOR AND FRANCIS"^^ . . . "PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY"^^ . . . . . . . . . . . . . . . . . "Jitender"^^ . "Nandal"^^ . "Jitender Nandal"^^ . . "Himanshu"^^ . "Verma"^^ . "Himanshu Verma"^^ . . "Debendra K."^^ . "Sahoo"^^ . "Debendra K. Sahoo"^^ . . "Kanti N."^^ . "Mihooliya"^^ . "Kanti N. Mihooliya"^^ . . . . . "HTML Summary of #3107 \n\nStudies on a new antimicrobial peptide from Vibrio proteolyticus MT110\n\n" . "text/html" . . . "QR Microbiology"@en . .