@article{open3112,
          volume = {16},
          number = {1},
          author = {Rahul Dilawari and Gaurav Kumar Chaubey and Radheshyam Modanwal and Asmita Dhiman and Sharmila Talukdar and Ajay Kumar and Chaaya Iyengar Raje and Manoj Raje},
            note = {The copyright of this article belongs to KARGER },
           title = {Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells},
       publisher = {KARGER },
            year = {2024},
         journal = {JOURNAL OF INNATE IMMUNITY},
           pages = {133--142},
        keywords = {ACE2; GAPDH; Inhibition; Innate immune defense; Severe acute respiratory syndrome coronavirus-2.},
             url = {http://crdd.osdd.net/open/3112/},
        abstract = {Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.}
}