%0 Journal Article
%A Dilawari, Rahul
%A Chaubey, Gaurav Kumar
%A Modanwal, Radheshyam
%A Dhiman, Asmita
%A Talukdar, Sharmila
%A Kumar, Ajay
%A Raje, Chaaya Iyengar
%A Raje, Manoj
%D 2024
%F open:3112
%I KARGER 
%J JOURNAL OF INNATE IMMUNITY
%K ACE2; GAPDH; Inhibition; Innate immune defense; Severe acute respiratory syndrome coronavirus-2.
%N 1
%P 133-142
%T Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells
%U http://crdd.osdd.net/open/3112/
%V 16
%X Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.
%Z The copyright of this article belongs to KARGER