TY  - JOUR
N1  - The copyright of this article belongs to KARGER 
ID  - open3112
UR  - http://crdd.osdd.net/open/3112/
IS  - 1
A1  - Dilawari, Rahul
A1  - Chaubey, Gaurav Kumar
A1  - Modanwal, Radheshyam
A1  - Dhiman, Asmita
A1  - Talukdar, Sharmila
A1  - Kumar, Ajay
A1  - Raje, Chaaya Iyengar
A1  - Raje, Manoj
Y1  - 2024///
N2  - Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.
PB  - KARGER 
JF  - JOURNAL OF INNATE IMMUNITY
VL  - 16
KW  - ACE2; GAPDH; Inhibition; Innate immune defense; Severe acute respiratory syndrome coronavirus-2.
TI  - Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells
SP  - 133
EP  - 142
ER  -