%A Rahul Dilawari
%A Gaurav Kumar Chaubey
%A Radheshyam Modanwal
%A Asmita Dhiman
%A Sharmila Talukdar
%A Ajay Kumar
%A Chaaya Iyengar Raje
%A Manoj Raje
%O The copyright of this article belongs to KARGER 
%J JOURNAL OF INNATE IMMUNITY
%T Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells
%X Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.
%N 1
%K ACE2; GAPDH; Inhibition; Innate immune defense; Severe acute respiratory syndrome coronavirus-2.
%P 133-142
%V 16
%D 2024
%I KARGER 
%R  10.1159/000535634
%L open3112