creators_name: Dilawari, Rahul
creators_name: Chaubey, Gaurav Kumar
creators_name: Modanwal, Radheshyam
creators_name: Dhiman, Asmita
creators_name: Talukdar, Sharmila
creators_name: Kumar, Ajay
creators_name: Raje, Chaaya Iyengar
creators_name: Raje, Manoj
type: article
datestamp: 2024-06-24 03:13:25
lastmod: 2024-06-24 03:13:25
metadata_visibility: show
title: Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells
ispublished: pub
subjects: QR
keywords: ACE2; GAPDH; Inhibition; Innate immune defense; Severe acute respiratory syndrome coronavirus-2.
note: The copyright of this article belongs to KARGER 
abstract: Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.
date: 2024
publication: JOURNAL OF INNATE IMMUNITY
volume: 16
number: 1
publisher: KARGER 
pagerange: 133-142
id_number:  10.1159/000535634
refereed: TRUE
citation:   Dilawari, Rahul and Chaubey, Gaurav Kumar and Modanwal, Radheshyam and Dhiman, Asmita and Talukdar, Sharmila and Kumar, Ajay and Raje, Chaaya Iyengar and Raje, Manoj  (2024) Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells.  JOURNAL OF INNATE IMMUNITY, 16 (1).  pp. 133-142.