title: Effect of the alpha-methyl substituent on chemoselectivity in esterase-catalyzed hydrolysis of S-acetyl sulfanylalkanoates.
creator: Kumar, Ish
creator: Jolly, R S
subject: QD Chemistry
description: The isomeric compounds 1 and 3, which differ only in the position of a methyl substituent, give opposite chemoselectivities in an esterase-catalyzed hydrolysis reaction. The esterase was chemoselective for the oxoester in 1, but for the thiol ester group in 3. A high enantioselectivity was observed for both 1 and 3.
publisher: ACS Publications
date: 1999-07-29
type: Article
type: PeerReviewed
format: application/pdf
identifier: http://crdd.osdd.net/open/313/1/jolly1999.pdf
relation: http://pubs.acs.org/doi/pdfplus/10.1021/ol990544%2B
identifier:   Kumar, Ish and Jolly, R S  (1999) Effect of the alpha-methyl substituent on chemoselectivity in esterase-catalyzed hydrolysis of S-acetyl sulfanylalkanoates.  Organic letters, 1 (2).  pp. 207-9.  ISSN 1523-7060     
relation: http://crdd.osdd.net/open/313/