%0 Journal Article
%@ 1523-7060
%A Kumar, Ish
%A Jolly, R S
%D 1999
%F open:313
%I ACS Publications
%J Organic letters
%N 2
%P 207-9
%T Effect of the alpha-methyl substituent on chemoselectivity in esterase-catalyzed hydrolysis of S-acetyl sulfanylalkanoates.
%U http://crdd.osdd.net/open/313/
%V 1
%X The isomeric compounds 1 and 3, which differ only in the position of a methyl substituent, give opposite chemoselectivities in an esterase-catalyzed hydrolysis reaction. The esterase was chemoselective for the oxoester in 1, but for the thiol ester group in 3. A high enantioselectivity was observed for both 1 and 3.
%Z Copyright of this article belongs to ACS.