@article{open3152, volume = {88}, number = {1}, month = {December}, author = {Yogesh Sharma and Ganesh P. Pawar and Vinod Chaudhari}, note = {The copyright of this article belongs to ACS Publications }, title = {One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O}, publisher = {ACS Publications }, year = {2022}, journal = {Journal of Organic Chemistry}, pages = {701--710}, url = {http://crdd.osdd.net/open/3152/}, abstract = {Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and {\ensuremath{\alpha}}-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners. } }