title: One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O
creator: Sharma, Yogesh 
creator: Pawar, Ganesh P.
creator: Chaudhari, Vinod
subject: QR Microbiology
description: Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and α-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners.    
publisher: ACS Publications 
date: 2022-12
type: Article
type: PeerReviewed
relation: https://pubs.acs.org/doi/10.1021/acs.joc.2c02171
identifier:   Sharma, Yogesh  and Pawar, Ganesh P. and Chaudhari, Vinod  (2022) One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O.  Journal of Organic Chemistry, 88 (1).  pp. 701-710.      
relation: http://crdd.osdd.net/open/3152/