%0 Journal Article
%A Sharma, Yogesh 
%A Pawar, Ganesh P.
%A Chaudhari, Vinod
%D 2022
%F open:3152
%I ACS Publications 
%J Journal of Organic Chemistry
%N 1
%P 701-710
%T One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O
%U http://crdd.osdd.net/open/3152/
%V 88
%X Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and α-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners.    
%Z The copyright of this article belongs to ACS Publications