%A Yogesh  Sharma
%A Ganesh P. Pawar
%A Vinod Chaudhari
%O The copyright of this article belongs to ACS Publications 
%J Journal of Organic Chemistry
%T One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O
%X Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and ?-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners.


%N 1
%P 701-710
%V 88
%D 2022
%I ACS Publications 
%R 10.1021/acs.joc.2c02171
%L open3152